SimThyr 3.2.2

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Thyroid hormones play an essential role for metabolism, growth and differentiation. Therefore, exact regulation of thyroid hormone levels is vital for most organisms. Although the principles of thyrotropic feedback control have been described decades ago we still have not yet gained comprehensive understanding of its dynamics. Recently, significant progress has been made with mathematical modelling of thyroid homeostasis. However, due to nonlinear interactions, these cybernetic modells cannot simultaneously describe static and dynamic behaviour. This gap may be filled with computer simulations that additionally facilitate an intuitive insight into the dynamics of thyrotropic feedback. SimThyr is a simulation program for the pituitary thyroid feedback control that is based on a parametrically isomorphic model of the overall system. Applications of this program cover research, including development of hypotheses, and education of students in biology and medicine, nurses and patients. SimThyr helped do prove a new hypothesis about the emergence of pulsatile TSH release. Furthermore it is used for educational processes at several locations.

Software OS: Windows 2000

Distribution:Open source

Download size:1.2MB

Instant FileName:SimThyr_3_2_2_Snapshot_20130126.zip

Renewed:January 27, 2013

Statistics counter:59 / 6 / 3 - DoDownload made 7.2 MB download traffic in the current month and 70.8 MB overall

Cost: free

System specs:Unspecified

SimThyr_3_2_2_Snapshot_20130126.zip file was thoroughly tested by our system on May 10, 2013 by the three antivirus programs and passed. Is absolutely clean, enjoy!
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History updates (Complete changelogs since the listing on this site)

3.2.2 [01-27-13]

Bug fix release. 3.2.2: Bugfixes (SVN commit r134, 26-I-2013). 3.2.2 Snapshot 20130126: Issue with parameter editor fixed (SVN commit r133, 26-I-2013) 3.2.2 Snapshot 20130120: Improved DIF export, crash after reset structure parameters
fixed (SVN commits r124 to r132, 20-I-2013)

Other versions : 3.2.1 3.2 3.1.1 3.1 3.0

v3.2.1 [11-04-12]

3.2.1: Bugfixes (SVN commits r119 and r120, 02-XI-2012). 3.2.1 Snapshot 20121031: Only Snapshot of SimThyr 3.2.1, nearly identical to final
version 3.2.1 (SVN commits r116 to r118, 31-X-2012).Milestone 3.2 3.2: Extended options for sensitivity analysis, including total T4 and T3 levels, TBG
and TBPA; bug fixes (SVN commits r108 to r112, 27-IX-2012).

v3.2 [10-04-12]

3.2: Extended options for sensitivity analysis, including total T4 and T3 levels, TBG
and TBPA; bug fixes (SVN commits r108 to 112, 27-IX-2012).

v3.1.1 [08-27-12]

3.1.1: New function to determine portal TRH level, bugfixes (SVN commits r80 to r82,
17-VII-2012). 3.1.1 Snapshot 20120717: Only Snapshot of SimThyr 3.1.1, nearly identical to final
version 3.1.1 (SVN commits r76 to r79, 17-VII-2012).Milestone 3.1 3.1: Final version 3.1 with some additions and fixes to the last snapshot, including
custom colours for tornado plots. (SVN commits r74 and r75, 31-V-2012). 3.1 Snapshot 20120518: More structure parameters for sensitivity analysis, flexible
legend position in tornado plot. (SVN commit r73, 18-V-2012).

v3.1 [06-10-12]

3.1: Final version 3.1 with some additions and fixes to the last snapshot, including
custom colours for tornado plots. (SVN commits r74 and r75, 31-V-2012). 3.1 Snapshot 20120518: More structure parameters for sensitivity analysis, flexible
legend position in tornado plot. (SVN commit r73, 18-V-2012).

v3.0 [12-13-11]

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Predicted future versions and notices:

The doDownload.com constantly monitors the update of all programs, including information from the SimThyr 3.2.3 changelog file, however sometimes it can happen that data are not complete or are outdated.We assume that author continue's to develop 3.3.0 version with further advanced features, and soon you will be informed. Equally important 4.0.0 upgrades of the program we will continue to monitor. Full SimThyr description has been compared with the overall software database and our algorithm has found the following applications (are showed below).

(1.2MB, Extension: ZIP)