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KEGG 66.1

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The increasing amount of genome sequence data is the basis for understanding life as a molecular system and for developing medical, pharmaceutical, and other practical applications. Since 1995 we have been developing knowledge-based methods for uncovering higher-order systemic behaviors of the cell and the organism from genomic and molecular information.The reference knowledge is stored in KEGG, Kyoto Encyclopedia of Genes and Genomes, and associated bioinformatics technologies are being developed both for basic research and practical applications.

Software OS:All OS
Distribution:Freeware
Download size:171.88MB
Instant FileName:vertebrate_mammalian1.genomic.fna.gz
Renewed:May 7, 2013
Statistics counter:173 / 8 / 3 - DoDownload made 1375.04 MB download traffic in the current month and 29735.24 MB overall
Cost: free
System specs:Unspecified
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vertebrate_mammalian1.genomic.fna.gz file was thoroughly tested by our system on Aug 24, 2011 by the three antivirus programs and passed. Is absolutely clean, enjoy!
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| Pathway Database | Ligand Database | Kegg | Kanehisa Laboratories | Brite Database |

History updates (Complete changelogs since the listing on this site)

66.1 [05-07-13]

The pathway map HTML pages are no longer statically generated. The URL such as /kegg/pathway/map/map00010.html will continue to be supported, but some old CGI programs that utilize static files do not work any longer. It is recommended to use "show_pathway" rather than "mark_pathway_www" for pathway map coloring (see KEGG WebLinks). Release 66.0, April 1, 2013
  • KEGG MEDICUS API, an addendum to KEGG API, is released. It allows handling of drug products marketed in Japan and the USA.
  • KEGG BRITE now contains html table files, such as for pharmacogenomic biomarkers.
  • KEGG reaction modules now contain variation patterns and combination patterns.

Other versions : 66.0 65.0 64.0 63.0 62.0 61.1 61.0 60.0 59.0 58.0 57.0 56.1 56.0 55.1 55.0

v66.0 [04-05-13]

KEGG MEDICUS API, an addendum to KEGG API, is released. It allows handling of drug products marketed in Japan and the USA.

  • KEGG BRITE now contains html table files, such as for pharmacogenomic biomarkers.
  • KEGG reaction modules now contain variation patterns and combination patterns.

    • v65.0 [01-01-13]

    A new metabolic pathway category, "Reaction module maps", is introduces. It contains pathway maps describing connection patterns of reaction modules.

  • The pathway category name "Overview" is changed to "Chemical structure transformation maps". The maps in this category are not expanded to organism-specific maps (just the reference pathway maps).
  • KEGG ENVIRON now contains an interface to environmental pollutants and other health-damaging substances stored in the KEGG COMPOUND database.

    • v64.0 [10-04-12]

    A new dataset of KEGG reaction modules is released.

  • KEGG DRUG now contains an interface to check a given set of drugs (D numbers) for any interactions associated with contraindications and precautions as described in the drug labels.
  • In the Japanese version of KEGG MEDICUS, this search can be performed for individual products (rather than D numbers).

    • v63.0 [07-09-12]

    The new REST-style version of KEGG API is released, together with an updated version of KEGG web links.

  • The KEGG organism code for the GENES database is no longer limited to three letters. Some may consist of four letters. Past releases Release 62.0, April 1, 2012
    • New "Reconstruct Pathway/Brite/Module" tools are made available in KEGG Mapper helping genome and metagenome annotations.
    • Another mapping tool, "Color Pathway 3D", is linked directly to KEGG Atlas 3D viewer.
    • "KEGG MEDICUS My Medication List" is released (Japanese version only).
    Release 61.1, February 1, 2012
    • The KEGG MEDICUS search now integrates FDA drug labels for both prescription and OTC drugs.
    • The search box in the KEGG top pages includes an option to select from KEGG search, DBGET search, and MEDICUS search.
    • A composite database named GENOMES is created consisting of GENOME for complete genomes in GENES and DGENES, EGENOME for EST datasets in EGENES, and MGENOME for environmental samples in MGENES.

    • v62.0 [04-16-12]

    New "Reconstruct Pathway/Brite/Module" tools are made available in KEGG Mapper helping genome and metagenome annotations.

  • Another mapping tool, "Color Pathway 3D", is linked directly to KEGG Atlas 3D viewer.
  • "KEGG MEDICUS My Medication List" is released (Japanese version only). Past releases Release 61.1, February 1, 2012
    • The KEGG MEDICUS search now integrates FDA drug labels for both prescription and OTC drugs.
    • The search box in the KEGG top pages includes an option to select from KEGG search, DBGET search, and MEDICUS search.
    • A composite database named GENOMES is created consisting of GENOME for complete genomes in GENES and DGENES, EGENOME for EST datasets in EGENES, and MGENOME for environmental samples in MGENES.

    • v61.1 [02-07-12]

    The KEGG MEDICUS search now integrates FDA drug labels for both prescription and OTC drugs.

  • The search box in the KEGG top pages includes an option to select from KEGG search, DBGET search, and MEDICUS search.
  • A composite database named GENOMES is created consisting of GENOME for complete genomes in GENES and DGENES, EGENOME for EST datasets in EGENES, and MGENOME for environmental samples in MGENES.

    • v61.0 [01-03-12]

    As of December 19, 2011 the KEGG database development was separated from the GenomeNet service. The KEGG team is responsible for the development of the 17 databses listed in the KEGG overview page. MGENES and EGENES as well as MGENOME and EGENOME are GenomeNet extensions of KEGG.

  • KEGG MEDICUS allows an intergrated search against KEGG PATHWAY, KEGG DISEASE, and KEGG DRUG.
  • The Japanese version of KEGG MEDICUS allows an intergrated search with package insert information of all prescription drugs and OTC drugs marketed in Japan.
  • The 3D map viewer linked from the new portal KEGG Cancer is integrated in KEGG Atlas.

    • v60.0 [10-08-11]

    KEGG Mapper now includes mapping tools for KEGG MODULE in addition to KEGG PATHWAY and KEGG BRITE.

  • A preliminary version of 3D map viewer is released and linked from the KEGG MEDICUS page.

    • v59.0 [08-02-11]

    KEGG FTP subscription is introduced.

  • The Color Pathway tool of KEGG Mapper now accepts numerical data, which can be displayed by gradation and optionally by 3D representation as well.

    • v58.0 [04-03-11]

    KEGG MEDICUS pathway maps indicating disease genes and drug targets are now treated as a special class of organism specific pathways with the organism code "hsadd".

  • This extension is also applied to organism specific BRITE hierarchies.
  • In a similar way, extended versions of ATC and other drug classification systems with target and metabolizing enzyme information are made available.

    • v57.0 [12-31-10]

    An enhanced version of KEGG MODULE is released containing computationally generated module maps, allowing KEGG module mapping similar to KEGG pathway mapping.

  • KEGG MEDICUS contains a collection of human pathway maps with known disease genes and drug targets marked in different colors, which can be used in the "Search Pathway" tool of KEGG Mapper. Past releases Release 56.1, December 1, 2010
    • Newly developed xenobiotics degradation pathway maps have been released.

    • v56.1 [12-02-10]

    Newly developed xenobiotics degradation pathway maps have been released.

    v56.0 [10-05-10]

    KEGG MEDICUS is introduced as an interface to KEGG pathway maps containing disease genes and drug targets.

  • Disease/drug mapping and user data mapping links are added to KEGG pathway maps.
  • KEGG pathway mapping capabilities are enhanced for the display of combined pathways, for example, for human and gut microbiome.

    • v55.1 [09-08-10]

    KEGG MEDICUS that integrates KEGG DISEASE, KEGG DRUG, and various aspects of human body systems. Current release Release 55.1, September 1, 2010

    • Tab-delimited fields are better handled in the BRITE functional hierarchy files, including the JOIN operation of a BRITE file and a binary relation file.
    • The collection of KEGG PATHWAY and BRITE mapping tools is now called KEGG Mapper.

    v55.0 [07-06-10]

    KEGG MEDICUS that integrates KEGG DISEASE, KEGG DRUG, and various aspects of human body systems. Current release Release 55.0, July 1, 2010

    • A new database of reaction class, KEGG RCLASS, is released for the grouping of similar reactions on the KEGG pathway maps, based on the RDM patterns of main reactant pairs.
    • A drug extension (or extra) database, KEGG EDRUG, is released containing crude drugs and other plant natural products, distinguishing from the collection of approved drugs in KEGG DRUG.
    • KEGG PLANT is discontinued and merged into KEGG EDRUG.
    • An updated version of KEGG Atlas now handles the global maps with layer information such as pathway modules.
    • An updated version of show_organism interface now handles dynamically generated maps for DGENES/EGENES/MGENES in a similar way as those for GENES.

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    Predicted future versions and notices:

    The doDownload.com constantly monitors the update of all programs, including information from the KEGG 66.1 changelog file, however sometimes it can happen that data are not complete or are outdated.We assume that author continue's to develop 66.2 version with further advanced features, and soon you will be informed. Equally important 67.0 upgrades of the program we will continue to monitor. Full KEGG description has been compared with the overall software database and our algorithm has found the following applications (are showed below).

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